Engineering polyketide production
β Scribed by Sinclair, Meeghan
- Book ID
- 109828931
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 171 KB
- Volume
- 18
- Category
- Article
- ISSN
- 1087-0156
- DOI
- 10.1038/79355
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Three elements came together during the past year to provide the opportunity to generate new polyketides. The first was the availability of cloned genes for several metabolic pathways; the second was a genetically defined host strain able to support the production of polyketides; and the third was t
The structural and catalytic similarities between modular nonribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) inspired us to search for hybrid NRPS-PKS systems. By examining the biochemical and genetic data known to date for the biosynthesis of hybrid peptide-polyketide natural prod