Engineering pharmaceutical stability with amorphous solids
β Scribed by Christopher J. Roberts; Pablo G. Debenedetti
- Publisher
- American Institute of Chemical Engineers
- Year
- 2002
- Tongue
- English
- Weight
- 344 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0001-1541
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π SIMILAR VOLUMES
The existence of different solid-state forms such as polymorphs, solvates, hydrates, and amorphous form in pharmaceutical drug substances and excipients, along with their downstream consequences in drug products and biological systems, is well documented. Out of these solid states, amorphous systems
In recent years, considerable effort has been directed towards correlating molecular mobility with the physical as well as chemical stability of amorphous pharmaceuticals. Global mobility (molecular motions associated with glass transition) has been the focus of most of these studies. However, in se