Engineering of Phenylboronic Acid Based Glucose-Sensitive Microgels with 4-Vinylpyridine for Working at Physiological pH and Temperature
✍ Scribed by Zahoor H. Farooqi; Weitai Wu; Shuiqin Zhou; Mohammad Siddiq
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 304 KB
- Volume
- 212
- Category
- Article
- ISSN
- 1022-1352
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✦ Synopsis
Abstract
Glucose‐sensitive p(NIPAM‐4‐VP‐PBA) microgels with different 4‐VP content are synthesized by the functionalization of p(NIPAM‐4‐VP‐AA) microgels with 3‐aminophenylboronic acid. The glucose‐, pH‐, and thermosensitive behavior of the microgels are investigated using DLS. The feeding content of the hydrophilic 4‐VP group increases the hydrodynamic radius and volume phase transition temperature of the resultant microgel. The effect of 4‐VP content on hydrodynamic radius and volume phase transition is systematically studied at different pH values. The effect of 4‐VP content on the glucose sensitivity is studied at physiological pH and temperature. The Lewis base moiety 4‐VP adjusts the working pH of the PBA‐based glucose‐responsive microgel to physiological values. magnified image