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Engineering novel proteins by transfer of active sites to natural scaffolds

โœ Scribed by Claudio Vita

Book ID
104362016
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
659 KB
Volume
8
Category
Article
ISSN
0958-1669

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โœฆ Synopsis

Novel functional proteins have been generated by the transfer of active sites to structurally homologous proteins and to new structural contexts. The most successful examples of these approaches succeeded in providing effective new tools in biochemistry and protein chemistry and in suggesting new models in drug design. Addresses Commissariat a I'Energie Atomique, Departement d'tngenierie et d'Etudes des Proteines,

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โœ Claudio Vita; Jean Vizzavona; Eugenia Drakopoulou; Sophie Zinn-Justin; Bernard G ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› Wiley (John Wiley & Sons) ๐ŸŒ English โš– 158 KB

Small multidisulfide-containing proteins are attractive structural templates to produce a biologically active conformation that mimics the binding surface of natural large proteins. In particular, the structural motif that is evolutionary conserved in all scorpion toxins has a small size ( 30 -40 am