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Engineering mesenchymal stem cells with hypoxia-regulated gene system: A promising approach for effective cell therapy

✍ Scribed by Yao Liang Tang; M.Ian Phillips; Vinay Badhwar


Book ID
113675980
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
53 KB
Volume
199
Category
Article
ISSN
1072-7515

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## Abstract ## Background We proposed to exploit hypoxia‐inducible factor (HIF)‐1Ξ± overexpression in prostate tumours and use this transcriptional machinery to control the expression of the suicide gene cytosine deaminase (CD) through binding of HIF‐1Ξ± to arrangements of hypoxia response elements.