Engineering Drug Delivery Systems (Woodhead Publishing Series in Biomaterials)

✍ Scribed by Ali Seyfoddin (editor), Seyedehsara Masoomi Dezfooli (editor), Carol Ann Greene (editor)

• Publisher: Woodhead Publishing
• Year: 2019
• Tongue: English
• Leaves: 249
• Series: Woodhead Publishing Series in Biomaterials
• Edition: 1
• Category: Library

✦ Synopsis

Engineering Drug Delivery Systems is an essential resource on a variety of biomaterials engineering approaches for creating drug delivery systems that have market and therapeutic potential. The book comprehensively discusses recent advances in the fields of biomaterials and biomedical sciences in relation to drug delivery. Chapters provide a detailed introduction to various engineering approaches in designing drug delivery systems, delve into the engineering of body functions, cover the selection, design and evaluation of biomaterials, and discuss the engineering of colloids as drug carriers. The book's final chapters address the engineering of implantable drug delivery systems and advances in drug delivery technology.

This book is an invaluable resource for drug delivery, materials scientists and bioengineers within the pharmaceutical industry.

✦ Table of Contents

Engineering Drug Delivery Systems
Copyright
Contents
List of contributors
1 Novel drug delivery systems
List of abbreviations
1.1 Introduction
1.2 SMART nanocarrier-based drug delivery systems
1.2.1 Mechanisms of nanocarrier transport throughout the systemic circulation reaching the specific target
1.2.1.1 Passive targeting
1.2.1.2 Active targeting
1.2.1.3 Responsive to stimuli targeting
1.2.2 Types of nanocarrier-based drug delivery system
1.2.2.1 Liposomes
1.2.2.2 Polymeric micelles
1.2.2.3 Dendrimers
1.2.2.4 Nanoparticles
1.3 SMART extended release drug delivery system
1.4 Novel technique for nanocarrier fabrication: microfluidics
1.5 Summary and conclusion
References
2 Formulation design in drug delivery
2.1 Introduction to formulation design
2.2 Route of administration
2.2.1 Peroral route
2.2.2 Parenteral route
2.2.3 Pulmonary route
2.2.4 Nasal route
2.2.5 Transdermal route
2.2.6 Implants
2.3 Nonbiodegradable materials for drug delivery
2.4 Biodegradable materials for drug delivery
2.4.1 Biodegradable polymer classification
2.4.1.1 Natural polymers
2.4.1.2 Synthetic polymers
2.4.2 Mechanisms of degradation
2.4.2.1 Hydrolytic degradation
2.4.2.2 Enzymatic degradation
2.5 Material surface properties
2.5.1 Surface morphology
2.5.2 Physiological factors
2.5.3 Surface and interfacial energies
2.5.4 Surface charge
2.5.5 Mechanical effects
2.5.6 Adjusting material surface properties for specific applications
2.5.6.1 Physical techniques
2.5.6.2 Chemical process
2.6 Structural and bulk properties
2.7 Material size
2.8 Material shape
2.9 Smart materials for drug delivery
2.9.1 Temperature-responsive polymers
2.9.2 pH-responsive polymers
2.9.3 Field-responsive polymers
2.9.3.1 Light-responsive
2.9.3.2 Electric field-responsive
2.9.4 Bio-responsive polymers
2.9.4.1 Glucose-responsive polymers
2.9.4.2 Enzyme-responsive polymers
2.9.4.3 Antigen and antibody-responsive polymers
2.10 Target cites
2.10.1 Brain targeting
2.10.2 Colon targeting
2.10.3 Cancer tissues targeting
2.10.3.1 Passive cancer targeting
2.10.3.2 Active cancer targeting
2.11 Conclusion
References
3 Formulation development and characterization
3.1 From lab to clinical trials: different stages of developing a drug delivery system
3.2 Technological aspects of a novel drug delivery system
3.2.1 Preparation of drug carriers by emulsion/suspension techniques
3.2.1.1 Pharmaceutical suspensions
3.2.1.2 Pharmaceutical foams
3.2.1.3 Emulsions
3.2.2 Microfabrication and molding of pharmaceuticals
3.2.2.1 Materials used for injection molding
3.2.2.2 Manufacturing parameters
3.2.2.3 Application of injection molding technology
3.2.3 Microfluidic technologies for drug delivery
3.2.4 Solid freeform fabrication of drug delivery systems
3.2.4.1 Three-dimensional printing
3.2.4.2 Stereolithography
3.2.4.3 Fused deposition modeling
3.2.4.4 Selective laser sintering
3.2.4.5 Bioplotting
3.2.4.6 Phase-change jet printing
3.3 Physiochemical characterization of drug delivery systems
3.3.1 Morphology
3.3.1.1 Size
3.3.1.2 Porosity
3.3.1.3 Microstructure
3.3.2 Physical properties
3.3.2.1 Mechanical properties
3.3.2.2 X-ray powder diffraction
3.3.2.3 Differential scanning calorimetry
3.3.3 Chemical properties
3.3.3.1 Fourier-transform infrared spectroscopy
3.3.4 Stability and biodegradability
3.4 Simulating a physiological environment for in vitro drug delivery studies
3.5 In vitro and in vivo toxicity studies
3.5.1 In vitro toxicity studies
3.5.2 In vivo toxicity studies
3.6 In vivo performance evaluations
3.7 Correlation between in vivo and in vitro studies
3.7.1 Correlation levels
3.7.1.1 Level A correlation
3.7.1.2 Level B correlation
3.7.1.3 Level C correlation
3.7.1.4 Multiple-level C correlation
3.7.1.5 Level D correlation
References
Further reading
4 Nano- and microparticles as drug carriers
4.1 Introduction
4.2 Micro versus nanoparticles: physicochemical properties for drug delivery
4.3 Types of carriers for drug delivery
4.3.1 Carriers based on lipids
4.3.1.1 Liposomes
4.3.1.2 Solid lipid nanoparticles
4.3.1.3 Lipid nanocapsules
4.3.2 Carriers based on polymers
4.3.2.1 Nanospheres and nanocapsules
4.3.2.2 Dendrimers
4.3.2.3 Nanogels
4.3.2.4 Polymeric micelles and polymersomes
4.4 Biomedical applications of lipid-based nanocarriers
4.5 Biomedical applications of polymer-based nanocarriers
4.6 Final remarks and future perspectives
References
5 Implantable drug delivery systems
5.1 Introduction
5.2 Nondegradable polymers
5.3 Nondegradable subdermal implants
5.4 Nondegradable vaginal rings
5.5 Nondegradable ocular implants
5.6 Biodegradable implants
5.7 Biodegradable polymers
5.8 Injectable in situ forming implants
5.9 Bioresorbable ceramics
5.10 Biodegradable metal alloys
References
Further reading
6 Three-dimensional printed drug delivery systems
6.1 Introduction
6.2 Direct write: pressure-assisted systems
6.3 Fused deposition modeling
6.4 Inkjet printing
6.4.1 Drop-on-solid inkjet printing
6.4.2 Drop-on-drop inkjet printing
6.5 Summary and future perspectives
References
7 Intelligent drug delivery systems
7.1 Introduction
7.1.1 Active and passive drug delivery
7.1.2 Hydrogel drug delivery systems
7.1.3 Thermoplastic drug delivery systems
7.1.4 Microdevices delivery systems
7.1.5 Transdermal patches delivery systems
7.1.6 Emerging therapeutic methods based on implantable drug delivery systems
7.1.6.1 Cancer immunotherapy
7.1.6.2 Delivery of immunomodulatory factors
7.1.6.3 Delivery of cells for adoptive cell transfer
7.1.7 Summary
References
8 Polymers and hydrogels to deter drug abuse
8.1 Introduction
8.1.1 Prescription drug abuse
8.1.2 Routes of abuse
8.2 Abuse deterrent formulations
8.3 Polymer properties in the abuse-deterrent products
8.3.1 Thermal
8.3.2 Rheological
8.3.3 Swelling
8.3.4 Mechanical
8.3.5 Binding
8.3.6 Film-forming
8.4 Conclusion
References
9 Glucose-sensitive materials for delivery of antidiabetic drugs
9.1 Introduction
9.1.1 Types and causes of diabetes
9.1.2 Diabetes management
9.2 Need to redesign insulin delivery systems
9.3 Glucose-sensitive materials
9.3.1 Glucose oxidase
9.4 Advantages and limitations of glucose oxidase-based systems
9.4.1 Concanavalin A
9.5 Advantages and limitations of concanavalin A-based systems
9.5.1 Phenylboronic acid
9.6 Advantages and limitations of phenylboronic acid
9.7 Conclusion
References
Further reading
Index