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Engineering Chiral Catalysts through Asymmetric Activation and Super High Throughput Screening (SHTS)

✍ Scribed by Koichi Mkami; Toshinobu Korenaga; Satoru Matsukawa; Kui-Ling Ding; Jiang Long

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 882 KB
Volume: 19
Category: Article
ISSN: 0256-7660
DOI: 10.1002/cjoc.20010190603

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✦ Synopsis

Abstract

A conceptually new strategy for asymmetric catalysis, namely asymmetric activation, in which a chiral activator selectively activates one enantiomer of a racemic chiral catalyst, and a highly efficient screening system for finding the most effective catalysts, namely super high throughput screening (SHTS), by which the reaction can be conducted in parallel and the ee% of the product is allowed to determine within minutes, are summarized in the present account. It is reasonable to believe that SHTS technique combined with asymmetric activation or deactivation principle will provide a very powerful methodology for finding the new catalysts and the best catalyst tuning for asymmetric reactions.

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