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Engineering and optimization of an allosteric biosensor protein for peroxisome proliferator-activated receptor γ ligands

✍ Scribed by Jingjing Li; Izabela Gierach; Alison R. Gillies; Charles D. Warden; David W. Wood


Book ID
113494012
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
980 KB
Volume
29
Category
Article
ISSN
0956-5663

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Peroxisome proliferator-activated receptor ␥ (PPAR␥) is expressed largely in adipose tissues and plays an important role in adipocyte differentiation. Several studies have recently shown that ligands of PPAR␥ could lead to growth inhibition in some malignancies. In our study, we focused on pancreati