Engineering and Application of Pluripotent Stem Cells

✍ Scribed by Ulrich Martin,Robert Zweigerdt,Ina Gruh (eds.)

Publisher: Springer International Publishing
Year: 2018
Tongue: English
Leaves: 232
Series: Advances in Biochemical Engineering/Biotechnology 163
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

This book reviews the latest biotechnological advances with pluripotent stem cells, exploring their application in tissue engineering and medicinal chemistry. Chapters from expert contributors cover topics such as the production of transgene-free induced pluripotent stem cells (iPSCs), expansion, controlled differentiation and programming of pluripotent stem cells, and their genetic instability. Particular attention is given to the application of the pluripotent stem cells for vascularision of engineered tissue and for drug screening.

This book will appeal to researchers working in regenerative medicine and drug discovery, and to bioengineers and professionals interested in stem cell research.

✦ Table of Contents

Front Matter ....Pages i-vii
Nonintegrating Human Somatic Cell Reprogramming Methods (Thorsten M. Schlaeger)....Pages 1-21
Scalable Expansion of Pluripotent Stem Cells (Neta Lavon, Michal Zimerman, Joseph Itskovitz-Eldor)....Pages 23-37
Scalable Cardiac Differentiation of Pluripotent Stem Cells Using Specific Growth Factors and Small Molecules (Henning Kempf, Robert Zweigerdt)....Pages 39-69
Specific Cell (Re-)Programming: Approaches and Perspectives (Frauke Hausburg, Julia Jeannine Jung, Robert David)....Pages 71-115
Bioengineered Cardiac Tissue Based on Human Stem Cells for Clinical Application (Monica Jara Avaca, Ina Gruh)....Pages 117-146
Human Pluripotent Stem Cells to Engineer Blood Vessels (Xin Yi Chan, Morgan B. Elliott, Bria Macklin, Sharon Gerecht)....Pages 147-168
Targeted Gene Editing in Human Pluripotent Stem Cells Using Site-Specific Nucleases (Sylvia Merkert, Ulrich Martin)....Pages 169-186
Acquired Genetic and Epigenetic Variation in Human Pluripotent Stem Cells (O. Kyriakides, J. A. Halliwell, P. W. Andrews)....Pages 187-206
Requirements for Using iPSC-Based Cell Models for Assay Development in Drug Discovery (Klaus Christensen, Filip Roudnicky, Christoph Patsch, Mark Burcin)....Pages 207-220
Back Matter ....Pages 221-228

✦ Subjects

Biotechnology

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