Lipopolysaccharide (LPS) triggers cytokine production through Toll-like receptor 4 (TLR4), which shares downstream signaling pathways with TLR2. We investigated the roles of TLR2 and TLR4 in Propionibacterium acnes (P. acnes)-primed, LPS-induced liver damage using selective TLR ligands. Stock LPS in
β¦ LIBER β¦
Engagement of Toll-like receptors by mycoplasmal superantigen: downregulation of TLR2 by MAM/TLR4 interaction
β Scribed by H.-H. Mu; N. D. Pennock; J. Humphreys; C. J. Kirschning; B. C. Cole
- Book ID
- 109037188
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 147 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1462-5814
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## Abstract Tollβlike receptor 2 (TLR2) is a pattern recognition receptor that plays an important role in enabling cells of the innate immune system to recognize conserved structural motifs on a wide array of pathogens including gramβpositive bacteria. Although microglia have recently been shown to