ENETS Consensus Guidelines for the Management of Patients with Digestive Neuroendocrine Neoplasms of the Digestive System: Well-Differentiated Pancreatic Non-Functioning Tumors

✍ Scribed by Falconi, Massimo; Bartsch, Detlef Klaus; Eriksson, Barbro; Klöppel, Günter; Lopes, José M.; O'Connor, Juan M.; Salazar, Ramón; Taal, Babs G.; Vullierme, Marie Pierre; O'Toole, Dermot

• Book ID: 121680179
• Publisher: S. Karger AG
• Year: 2012
• Tongue: English
• Weight: 845 KB
• Volume: 95
• Category: Article
• ISSN: 0028-3835
• DOI: 10.1159/000335587

✦ Synopsis

Classification and Epidemiology

The WHO 2010 classification [1] distinguishes between well-differentiated neuroendocrine tumors (NETs) and poorly differentiated neuroendocrine carcinomas (NECs) of small or large cell type. NETs are then divided according to a grading scheme based on mitotic count or Ki67 index in NETs-G1 (with a mitotic count ! 2 per 10 high-power fields (HPF) and/or ^ 2% Ki67 index), and NETs-G2 (with a mitotic count 2-20 per 10 HPF and/or 3-20% Ki67 index). All NECs are graded G3 (with a mitotic count 1 20 per 10 HPF and/or 1 20% Ki67 index).

Most pancreatic NF-NENs are well differentiated (i.e. NETs); NF-NECs are uncommon. NF-NETs have a crude