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Energy metabolism in tumor cells

✍ Scribed by Rafael Moreno-Sánchez; Sara Rodríguez-Enríquez; Alvaro Marín-Hernández; Emma Saavedra


Book ID
111311835
Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
596 KB
Volume
274
Category
Article
ISSN
1432-1327

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Tirapazamine is a hypoxic cell cytotoxin in phase II/III trials. To further understand its mechanism of action in vivo, we examined the effect of tirapazamine on tumor energy metabolism and pH. RIF-1 and SCCVII tumors were grown subcutaneously in the flanks of C3H mice. Tumor energy metabolism, expr