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Energy and Glutamate Dependency of 3-Nitropropionic Acid Neurotoxicity in Culture

โœ Scribed by Sheri L. Fink; Dora Y. Ho; Robert M. Sapolsky


Book ID
115606328
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
152 KB
Volume
138
Category
Article
ISSN
0014-4886

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3-Nitropropionic acid (3-NPA) is a selective and irreversible inhibitor of succinate dehydrogenase. The effect of this compound on the metabolism of [U-13 C]glutamate was studied in astrocytes using 13 C nuclear magnetic resonance spectroscopy. The appearance of [1,2,3-13 C]glutamate in cell extract