Energetics of Polar Side-Chain Interactions in Helical Peptides: Salt Effects on Ion Pairs and Hydrogen Bonds †

Hydrogen bonds between short polar side

Hydrogen bonds between short polar side chains and peptide backbone: Prevalence in proteins and effects on helix-forming propensities

✍ M. Vijayakumar; Hong Qian; Huan-Xiang Zhou 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 206 KB 👁 2 views

A survey of 322 proteins showed that the short polar (SP) side chains of four residues, Thr, Ser, Asp, and Asn, have a very strong tendency to form hydrogen bonds with neighboring backbone amides. Specifically, 32% of Thr, 29% of Ser, 26% of Asp, and 19% of Asn engage in such hydrogen bonds. When an