A conformational study of poly-L-serine has shown that it can exist in the left-handed ฮฑ-helical form. A study of a pair of peptide units with the serine sidegroup attached to the ฮฑ carbon atom linking the two units showed that O๏ฃฟH โO hydrogen bonds between the OH group of the side chain and a carbo
Energetics of left-handed helix formation of nucleic acids
โ Scribed by H.H. Klump
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 749 KB
- Volume
- 119
- Category
- Article
- ISSN
- 0040-6031
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๐ SIMILAR VOLUMES
we have calculated a theoretical counterpart of this idealized double helix by constraining the helical twist and rise to their experimental values ( -45' and 2.33 A, respectively). Applying the same constraints to the parallel-stranded duplex, this also leads to a low-energy structure with wide cen
## Abstract The design of modified nucleic acid aptamers is improved by considering thermodynamics and kinetics of their association/dissociation processes. Locked Nucleic Acids (LNA) is a promising class of nucleic acid analogs. In this work the thermodynamic and kinetic properties of a LNA quadru