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Energetics of Cation Radical Formation at the Proximal Active Site Tryptophan of Cytochrome c Peroxidase and Ascorbate Peroxidase

✍ Scribed by Jensen, G. M.; Bunte, S. W.; Warshel, A.; Goodin, D. B.


Book ID
126210677
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
219 KB
Volume
102
Category
Article
ISSN
0022-3654

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The activated state of cytochrome c peroxidase, compound ES, contains a cation radical on the Trp-191 side chain. We recently reported that replacing this tryptophan with glycine creates a buried cavity at the active site that contains ordered solvent and that will specifically bind substituted imid