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Energetics and Cooperativity of the Hydrogen Bonding and Anchor Interactions that Bind Peptides to MHC Class II Protein

โœ Scribed by Benjamin J. McFarland; John F. Katz; Andrea J. Sant; Craig Beeson


Book ID
116662186
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
410 KB
Volume
350
Category
Article
ISSN
0022-2836

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Binding interactions between peptides an
โœ Benjamin J. McFarland; Craig Beeson ๐Ÿ“‚ Article ๐Ÿ“… 2002 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 464 KB

## Abstract The activation of helper T cells by peptides bound to proteins of the class II Major Histocompatibility Complex (MHC II) is pivotal to the initiation of an immune response. The primary functional requirement imposed on MHC II proteins is the ability to efficiently bind thousands of diff