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Energetic Variational Analysis EnVarA of Ions in Calcium and Sodium Channels

โœ Scribed by Eisenberg, Robert S.; Hyon, Yunkyong; Liu, Chun

Book ID
122185105
Publisher
Biophysical Society
Year
2010
Tongue
English
Weight
49 KB
Volume
98
Category
Article
ISSN
0006-3495

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## Structure-function studies have shown that it is possible to convert a sodium channel to a calcium-selective channel by a single amino acid substitution in the selectivity filter locus. Ion permeation through the "model selectivity filter" was modeled with a reduced set of functional groups repr