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Endoxifen and Other Metabolites of Tamoxifen Inhibit Human Hydroxysteroid Sulfotransferase 2A1 (hSULT2A1)

✍ Scribed by Squirewell, E. J.; Qin, X.; Duffel, M. W.

Book ID
127185548
Publisher
American Society for Pharmacology and Experimental Therapeutics
Year
2014
Tongue
English
Weight
897 KB
Volume
42
Category
Article
ISSN
0090-9556

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## Abstract Cytosolic sulfotransferases (SULTs) are a major family of phase II drug‐metabolizing enzymes. SULT‐catalyzed sulfonation regulates hormone activities metabolizes drugs detoxifies xenobiotic toxicants bioactivates carcinogens. Human dehydroepiandrosterone sulfotransferase (hSULT2A1 DHEA‐