Endotoxins isolated from the air of a Danish paper mill and the relation to change in lung function: An 11-year follow-up
✍ Scribed by Torben Sigsgaard; Lone Donbæk Jensen; Anette Abell; Helle Würtz; Gert Thomsen
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 109 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0271-3586
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Background
A decline in lung function has been associated with farming, cotton spinning, and work in the animal feed industry. The aim of the study was to reveal if loss of lung function was associated to work at a paper mill.
Methods
Ninety‐seven male paper workers (PW), and 55 control workers were examined. Hygiene samples included total dust, endotoxins, and microorganisms. Interview, pulmonary function testing, and skin prick test (SPT) were performed and yearly decline in lung function was calculated.
Results
The exposure for endotoxin (LPS) ranged from Median (Max−Min) 69 (370−6) EU/m^3^, in the wet‐end of the paper machines to 6 (19−16) in the pulping area. The lung function decline among the controls was comparable to the decrements among the maintenance and repair workers at the paper factory, around 51–54 and 37–38 ml/year among smokers' and non‐smokers, respectively. After adjustment for baseline FEV~1~, the variables associated to an increased loss of FEV~1~ were age smoking and cough. For FVC we found an inverse relation between exposure and yearly decline.
Conclusion
No increase in loss of lung function is seen among workers exposed to up to 200 EU/m^3^ of LPS. Am. J. Ind. Med. 46:327–332, 2004. © 2004 Wiley‐Liss, Inc.