Endotoxin rejection by ultrafiltration through high-flux, hollow fiber filters
✍ Scribed by Yamamoto, Chieko ;Kim, Sung-Teh
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 482 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0021-9304
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✦ Synopsis
The efficacy of endotoxin (ET) rejection of four hollow fiber membranes with comparable sieving properties was evaluated in an ultrafiltration experiment. The solution conditioned with type I lipopolysaccharide (LPS) from Esckerickiu Cali, 80,000 endotoxin units (EU) /L, was filtered through polyesterpolymer alloy (PEPA), polymethyl methacrylate (PMMA), polyacrylonitrile (PAN), and polysulfone (PS) membranes. The ET activity of the filtrate was not detectable in PEPA and PMMA, 6.4 f .04 (mean 5 SD) EU/L in PAN, and 10.3 f 1.1 EU/L in PS. The ET activity of the filtrate of type I1 LPS from Acinetabacter solution, 80,000 EU/L, was