Endotoxin inhibition of dexamethasone induction of tryptophan oxygenase in suspension culture of isolated rat parenchymal cells: Involvement of the hepatic nonparenchymal cell fraction

Persistent activation of nuclear factor-

Persistent activation of nuclear factor-κB in cultured rat hepatic stellate cells involves the induction of potentially novel rel-like factors and prolonged changes in the expression of IκB family proteins

✍ Ahmed M. Elsharkawy; Matthew C. Wright; Ron T. Hay; Michael J. Arthur; Timothy H 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 228 KB 👁 1 views

## Rat hepatic stellate cells (HSC ) cultured in serumcontaining medium underwent a rapid (3-hour) classical induction of p50:p65 and p65:p65 nuclear factor-B (NF-B) dimers. Subsequent culturing was associated with prolonged expression of active p50:p65 and persistent induction of a high-mobility