Endotoxin impairs biliary transport of sparfloxacin and its glucuronide in rats
โ Scribed by Masayuki Nadai; Ying Lan Zhao; Li Wang; Yuki Nishio; Kenji Takagi; Kiyoyuki Kitaichi; Kenzo Takagi; Hideo Yoshizumi; Takaaki Hasegawa
- Book ID
- 114014399
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 93 KB
- Volume
- 432
- Category
- Article
- ISSN
- 0014-2999
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Cholestasis in patients with sepsis has been attributed to the effects of endotoxin (lipopolysaccharides, LPS) and LPS-induced cytokines, which are also potent stimulators of systemic and hepatic nitric oxide (NO) synthesis. NO donors stimulate bile acid-independent bile flow in normal rat liver, bu
Endotoxin is known to cause a dose-dependent impairment of hepatic bile secretion, organic anion excretion, and activity of Na+,K'-activated ATPase. Since it is possible that this impaired excretory function is a result of direct interaction of endotoxin with hepatocytes, we examined: (a) the excret