𝔖 Bobbio Scriptorium
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Endotoxin alters spontaneous transmitter release at the frog neuromuscular junction

✍ Scribed by Ph.D. Robert J. Person

Publisher
John Wiley and Sons
Year
1977
Tongue
English
Weight
575 KB
Volume
3
Category
Article
ISSN
0360-4012

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✦ Synopsis

Abstract

The direct neurotoxic effects of E. coli endotoxin (ETX) on spontaneous transmitter release were tested at the frog sartorius muscle neuromuscular junction. Spontaneous transmitter release was monitored by intracellularly recording miniature end‐plate potentials (MEPPs). Junctions were continuously exposed to standard concentrations of 10ΞΌg/ml of 3 ETX sample, 2 of which produced a significant elevation of MEPP frequency followed by a decline of frequency to very low rates. The third ETX sample, known to have a decreased canine lethality, was with out effect on MEPP frequency. No significant changes in MEPP amplitude were evident. The rate of change in MEPP frequency, but not the peak frequency, was reduced by lowering ETX concentrations. Alterations in MEPP frequency induced by ETX were prevented by removing Ca^++^ and antagonized by high [k^+^] out. The results suggest that ETX alters ion conductance channels, particularly those for Ca^++^, in the presynaptic terminal membrane.

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