Endothelin stimulates cardiac α- and β- myosin heavy chain gene expression
✍ Scribed by D.L. Wang; J.J. Chen; N.L. Shin; Y.C. Kao; K.H. Hsu; W.Y. Huang; C.C. Liew
- Book ID
- 117055048
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 577 KB
- Volume
- 183
- Category
- Article
- ISSN
- 0006-291X
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The ␣and -myosin genes extend over 51 kb on chromosome 14 in human and 11 in mouse separated by about 4.5 kb of intergenic sequence. They are located in tandem in the order of their expression during development. Transcription of each gene is independently controlled but coordinately regulated. Dur
Several neuroendocrine factors have been shown to influence the muscle phenotype. Various physiological reports have suggested the role of adrenergic nervous system for cardiac myosin heavy chain (MHC) expression. We have used cultured fetal rat heart myocytes to investigate the role of cAMP on the