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Endothelin receptor antagonists are not beneficial in the therapy of acute experimental pancreatitis

✍ Scribed by M.E. Martignoni; G.O. Ceyhan; E. Ayuni; Y. Kondo; A. Zimmermann; M.W. Büchler; H. Friess


Publisher
Springer
Year
2004
Tongue
English
Weight
666 KB
Volume
389
Category
Article
ISSN
1435-2451

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Endothelin-3 (ET-3) elicited a concentration-dependent positive inotropic effect on rabbit papillary muscle, the maximal response being approximately 65% of the maximal response to isoproterenol. ET-1 induced a positive inotropic effect over the concentration range below 10(-9) M, at which ET-3 did