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Endothelin rapidly stimulates tyrosine phosphorylation in osteoblast-like cells

✍ Scribed by Iris Schvartz; Olivia Ittoop; Giora Davidai; Eli Hazum


Book ID
119142671
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
780 KB
Volume
13
Category
Article
ISSN
0196-9781

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To investigate how mechanical loading stimulates bone cells, we subjected murine osteoblast-like cells, MC3T3E1, to fluid flow generated by shaking culture dishes. Since we had previously found that egr-1 mRNA is up-regulated by the flow, and that the regulation involves tyrosine kinase, we examined