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Endothelin and structurally related analogs distinguish between endothelin receptor subtypes

✍ Scribed by Robert L. Panek; Terry C. Major; Gary P. Hingorani; Annette M. Doherty; David G. Taylor; Stephen T. Rapundalo


Book ID
115764954
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
352 KB
Volume
183
Category
Article
ISSN
0006-291X

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## Abstract The molecular basis for recognition of peptide ligands endothelin‐1, ‐2 and ‐3 in endothelin receptors is poorly understood. Especially the origin of ligand selectivity for ET~A~ or ET~B~ is not clearly resolved. We derived sequence‐structure‐function relationships of peptides and recep