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Endothelin-1 is biologically active in experimental rat obliterative bronchiolitis

✍ Scribed by V.P Pulkkinen; J.M Tikkanen; K.B Lemström; P.K Koskinen

Book ID
117230123
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
55 KB
Volume
33
Category
Article
ISSN
0041-1345

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The effect of endothelin (ET) 1 on intracellular Ca 2؉ transients in cultured rat hepatic stellate cells (HSCs) during transformation was studied by use of single-cell fluorescence. Regardless of the duration of HSC culture, ET-1 caused a BQ-123-sensitive but IRL-1038-insensitive elevation of [Ca 2؉