Endothelin-1 induces vascular endothelial growth factor synthesis in osteoblasts Involvement of p38 mitogen-activated protein kinase
β Scribed by Osamu Kozawa; Hidenori Kawamura; Daijiro Hatakeyama; Hiroyuki Matsuno; Toshihiko Uematsu
- Book ID
- 114283451
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 120 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0898-6568
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We previously showed that basic fibroblast growth factor (bFGF)-induced activation of protein kinase C (PKC) via phosphatidylinositol-hydrolyzing phospholipase C and phosphatidylcholine-hydrolyzing phospholipase D suppresses interleukin-6 (IL-6) synthesis by bFGF itself in osteoblast-like MC3T3-E1 c
## Abstract We previously reported that endothelinβ1 (ETβ1) activates both p44/p42 mitogenβactivated protein (MAP) kinase and p38 MAP kinase in osteoblastβlike MC3T3βE1 cells, and that not p44/p42 MAP kinase but p38 MAP kinase participates in the ETβ1βinduced vascular endothelial growth factor (VEG