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Endothelin-1 induces hypoxia inducible factor 1α expression in pulmonary artery smooth muscle cells

✍ Scribed by Manxiang Li; Yuan Liu; Faguang Jin; Xiuzhen Sun; Zongfang Li; Yun Liu; Ping Fang; Hongyang Shi; Xingtang Jiang

Book ID: 118442972
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 384 KB
Volume: 586
Category: Article
ISSN: 0014-5793
DOI: 10.1016/j.febslet.2012.08.036

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## Abstract Hypoxia promotes angiogenesis by modulating the transcriptional regulator hypoxia‐inducible factor 1α (HIF‐1α). HIF‐1α is a master regulator of the hypoxic response, and its proangiogenic activities include, but are not limited to, regulation of vascular endothelial growth factor (VEGF)