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Endothelin-1-induced proliferation of human endothelial cells depends on activation of K+ channels and Ca2+ influx

✍ Scribed by Kuhlmann, C. R. W. ;Most, A. K. ;Li, F. ;Munz, B. M. ;Schaefer, C. A. ;Walther, S. ;Raedle-Hurst, T. ;Waldecker, B. ;Piper, H. M. ;Tillmanns, H. ;Wiecha, J.


Book ID
108601704
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
218 KB
Volume
183
Category
Article
ISSN
0001-6772

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The effect of pinacidil, an opener of ATP-sensitive K + (K ATP ) channels, on large-conductance Ca 2+ -activated K+ (BK Ca ) channels was investigated in cultured endothelial cells of human umbilical veins. In whole cell configuration, pinacidil (30 Β΅M) increased the amplitude of K + outward current