Endothelin-1 and big endothelin-1 in NIDDM patients with and without microangiopathy
β Scribed by Kyuzi Kamoi; Miyuki Ishibashi; Tohru Yamaji
- Book ID
- 119135532
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 488 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0168-8227
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## Abstract The complex pathogenesis of chronic renal disease (CRD) depends on endothelin (ET) axis (ETs and ET receptors) and nitric oxide (NO) because of their vasoactive effects and their role in general modulation of vascular homeostasis. Various renal cells synthesize ETs and NO that play a si
The possible diagnostic or prognostic significance of changes in circulating level of endothelins in a variety of pathological conditions is currently of interest. Unfortunately, no consensus regarding optimization of sensitivity and extraction procedures for the reliable radioimmunoassay of endothe