27708 (USA) [\*\*] M. W. G. and D. J. K. would like to thank the NIH for funding (R01-EB-000501). We thank the team at Affinergy Inc. for useful discussions, especially Dr. Greg Harbers for performing XPS studies, the technical staff at the Shared Materials Instrumentation Facility at Duke Universit
Endothelialization of polymer surfaces
β Scribed by Absolom, D. R. ;Hawthorn, L. A. ;Chang, G.
- Book ID
- 102874313
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 925 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0021-9304
No coin nor oath required. For personal study only.
β¦ Synopsis
The role that substrate surface properties play in influencing the extent of endothelialization of polymer surfaces has been investigated. For a wide range of polymer surfaces, the degree of endothelialization for both porcine and bovine endothelial cells is directly related to polymer surface tension: increased endothelialization occurring with increasing substrate surface tension. As a result of adsorption of the proteins in the culture media, the surface properties of the polymers are altered con-siderably. The protein-coated polymers were characterized by means of liquidliquid contact angle measurements under non-denaturing conditions. A striking correlation is observed between the degree of endothelialization and the measured dextran contact angle. The degree of endothelial cell spreading is not related to polymer surface tension. Cell morphology and extracellular matrix production, however, are influenced by substrate surface properties.
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