Endothelial ligands and homing of mucosal leukocytes in extraintestinal manifestations of IBD

✍ Scribed by Marko Salmi; Dr. Sirpa Jalkanen

• Book ID: 102862359
• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 822 KB
• Volume: 4
• Category: Article
• ISSN: 1078-0998
• DOI: 10.1002/ibd.3780040210

✦ Synopsis

Crohn's disease and ulcerative colitis are quite often complicated with manifestations in extraintestinal organs like joints, eye, and skin. Although the etiopathogenesis of these nonmucosal complications remains unsettled, they all share the characteristic feature of inappropriate leukocyte recruitment in nonlymphatic organs. Under normal conditions, lymphocytes recirculate between the blood and lymphoid organs in search of their cognate antigens, whereas polymorphonuclear leukocytes are excluded from tissues. On inflammation, the leukocyte trafficking changes dramatically. Granulocytes infiltrate into the inflammatory focus very rapidly, and they are followed by lymphocytes, especially activated irnmunoblasts and memory cells, which now also leave the vasculature at nonlymphoid tissues. Leukocyte extravasation from the blood