Endothelial cell–based systemic gene therapy of metastatic melanoma
✍ Scribed by Ojeifo, John O; Lee, Hyeran R; Rezza, Phyllis; Su, Ning; Zwiebel, James A
- Book ID
- 110017833
- Publisher
- Nature Publishing Group
- Year
- 2001
- Tongue
- English
- Weight
- 839 KB
- Volume
- 8
- Category
- Article
- ISSN
- 0929-1903
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
One of the many features of the malignant phenotype, in vitro and in vivo, is elevated heparanase production and activity. Using in vitro model systems, we examined the capacity of murine (B16B15b) and human (70W) brain-metastatic melanoma cells to degrade the subendothelial matrix produced by endot
Targeting cancer gene therapy to endothelial cells seems to be a rational approach, because (a) a clear correlation exists between proliferation of tumor vessels and tumor growth and malignancy, (b) differences of cell membrane structures between tumor endothelial cells and normal endothelial cells