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Endothelial capillaries chemotactically attract tumour cells

✍ Scribed by Cornelie von Bülow; Wiebke Hayen; Anke Hartmann; Wolfgang Mueller-Klieser; Bruno Allolio; Volker Nehls

Book ID
101321071
Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
343 KB
Volume
193
Category
Article
ISSN
0022-3417

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✦ Synopsis

Directional migration of capillaries towards tumour implants is generally assumed to be regulated by chemotaxis. Preliminary evidence has also been presented for the existence of a reverse chemotactic signalling pathway, with capillaries attracting tumour cells via paracrine factors. By using a variety of endothelial cell types and tumour cell lines, this study has systematically investigated chemotaxis between endothelial cells and tumour cells in two-and three-dimensional systems. Checkerboard analysis revealed faint attraction of human umbilical vein endothelial cells (HUVECs), but not porcine aortic endothelial cells (PAECs), by tumour cells. In reverse, both PAECs and HUVECs potently induced chemotactic migration of tumour cells. Using a microcarrier-based ®brin gel assay, directional migration of endothelial cells towards tumour cells was not observed. In reverse, tumour cells were strongly attracted by endothelial cells. Identi®cation of endothelium-derived chemotactic molecules may provide a valuable approach for the treatment of tumour metastasis.

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