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Endothelial and fibroblastic activation in scleroderma: The myth of the “uninvolved skin”

✍ Scribed by Henry N. Claman; Ralph C. Giorno; James R. Seibold

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
736 KB
Volume
34
Category
Article
ISSN
0004-3591

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✦ Synopsis

We studied the immunohistochemistry of the skin Of scleroderma patients to determine the differences (if any) between clinically "affected" and "nonaffected" areas. We examined paired skin biopsy samples from clinically involved forearm skin ("affected") and clinically uninvolved proximal skin ("nonaffected") taken from 19 patients with diffuse scleroderma and from 15 normal control subjects. We stained the sections with antibodies to endothelial leukocyte-adherence molecule type 1 (ELAM-1; to detect endothelial activation) and to procollagen.1 (PC-1; to detect newly formed, unprocessed collagen). There was increased expression Of ELAM-1 and PC-1 in sclerodermatous skin as compared with the controls, but there was no difference between From the

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