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Endothelial and Fibroblast Cell-Derived Heparan Sulphate Bind with Differing Affinity to Basic Fibroblast Growth Factor

✍ Scribed by David A. Pye; Shant Kumar

Book ID
115582478
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
136 KB
Volume
248
Category
Article
ISSN
0006-291X

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Heparan sulfate proteoglycans on the cell surface act as low affinity binding sites for acidic and basic fibroblast growth factor (FGF) [Moscatelli (1987): J Cell Physiol 131:123-1301 and play an important role in the interaction of FGF with the FGF receptor (FGFR). In this study, several aspects of