## Angiogenesis is essential for the development of a solid tumor, including hepatocellular carcinoma (HCC). HCC is a well-known hypervascular tumor. Vascular endothelial growth factor (VEGF) is one of the most potent angiogenic factors. Its role has not been clarified in vivo in HCC development.
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Endostatin gene transfer in murine lung carcinoma cells induces vascular endothelial growth factor secretion resulting in up-regulation of in vivo tumorigenecity
β Scribed by Ri Cui; Kazuhisa Takahashi; Fumiyuki Takahashi; Kenneth K. Tanabe; Yoshinosuke Fukuchi
- Book ID
- 116333675
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 322 KB
- Volume
- 232
- Category
- Article
- ISSN
- 0304-3835
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Vascular endothelial growth factor (VEGF), which is one of the most potent angiogenic factors, has been shown to play a pivotal role in tumor angiogenesis, including hepatocellular carcinoma (HCC). The effects of VEGF are mediated mainly through two distinct receptors, flt-1 and KDR/ Flk-1. It has b