Endoscopic ultrasound-guided fine-needle aspiration biopsy: A powerful tool to obtain samples from small lesions

✍ Scribed by Jhala, Nirag C. ;Jhala, Darshana ;Eltoum, Isam ;Vickers, Selwyn M. ;Wilcox, C. Mel ;Chhieng, David C. ;Eloubeidi, Mohamad A.

• Publisher: John Wiley and Sons
• Year: 2004
• Tongue: English
• Weight: 137 KB
• Volume: 102
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/cncr.20451

✦ Synopsis

Background:

Endoscopic ultrasound (eus) is a powerful imaging modality to identify and determine the extent of a lesion. in addition, eus is superior to a computed tomography scan in detecting lesions < 3 cm. the objective of the current study was to determine whether small lesions (< or = 25 mm) affected the specimen adequacy and the diagnostic accuracy for lesions aspirated under eus guidance.

Methods:

In the current study, 209 consecutive eus-guided fine-needle aspiration biopsy (eus-fnab) samples < or = 25 mm (100 samples) or > 25 mm (109 samples) as determined by eus were obtained from 151 patients with a mean age of 62 years (range, 39-94 years). a cytopathologist present in the endoscopy suite determined specimen adequacy. yield of adequate samples for diagnosis, number of passes, and operating characteristics of eus-fnab for small (< or = 25 mm) and large lesions (>25 mm) were compared.

Results:

The overall yield of obtaining adequate samples for diagnosis was 96% (201 of 209). there was no difference noted with regard to the yield of obtaining samples (96% vs. 96%) from small or large lesions. a mean of 2.5 passes (range, 1-9 passes) was needed to obtain adequate samples from lesions < or = 25 mm, whereas a mean of 4.5 passes (range, 1-11 passes) was needed to obtain adequate samples from lesions > 25 mm. the sensitivity (96% vs. 96%), specificity (100% vs. 100%), and diagnostic accuracy (98% vs. 97%) for eus-fnab were comparable whether the lesion was < or = 25 mm or > 25 mm.

Conclusions:

Eus-fnab was a highly effective technique to obtain samples from small (< or = 25 mm) and large (> 25 mm) lesions without affecting the sensitivity, specificity, or diagnostic accuracy.