Endoscopic identification and quantification of aberrant crypt foci in the human colon
β Scribed by Douglas G. Adler; Christopher J. Gostout; Darius Sorbi; Lawrence J. Burgart; Linan Wang; W.Scott Harmsen
- Book ID
- 118523276
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 99 KB
- Volume
- 56
- Category
- Article
- ISSN
- 1097-6779
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## Abstract The role of aberrant crypt foci (ACF) as preneoplastic lesions in colon carcinogenesis is not clear. In __Min__/+ mice and their wildβtype littermates treated with azoxymethane (AOM), we previously identified a subgroup of flat ACF that seem more immediate precursors of tumors than the
## Background: The authors examined somatic mutations of the adenomatous polyposis coli (apc) gene in 84 human aberrant crypt foci (acf) to determine whether apc gene mutations were involved in the histologic progression of acf. ## Methods: Mutation cluster regions of the apc gene were subjected