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Endoscopic identification and quantification of aberrant crypt foci in the human colon

✍ Scribed by Douglas G. Adler; Christopher J. Gostout; Darius Sorbi; Lawrence J. Burgart; Linan Wang; W.Scott Harmsen


Book ID
118523276
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
99 KB
Volume
56
Category
Article
ISSN
1097-6779

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## Abstract The role of aberrant crypt foci (ACF) as preneoplastic lesions in colon carcinogenesis is not clear. In __Min__/+ mice and their wild‐type littermates treated with azoxymethane (AOM), we previously identified a subgroup of flat ACF that seem more immediate precursors of tumors than the

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## Background: The authors examined somatic mutations of the adenomatous polyposis coli (apc) gene in 84 human aberrant crypt foci (acf) to determine whether apc gene mutations were involved in the histologic progression of acf. ## Methods: Mutation cluster regions of the apc gene were subjected