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Endoplasmic reticulum stress contributes to prediabetic peripheral neuropathy

✍ Scribed by Lupachyk, Sergey; Watcho, Pierre; Obrosov, Alexander A.; Stavniichuk, Roman; Obrosova, Irina G.

Book ID
120272079
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
714 KB
Volume
247
Category
Article
ISSN
0014-4886

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The unfolded protein response (UPR) is an evolutionarily conserved cell signaling pathway that is activated to regulate protein synthesis and restore homeostatic equilibrium when the cell is stressed from increased client protein load or the accumulation of unfolded or malfolded proteins. Once activ