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Endonuclease induced DNA damage and cell death in chemical hypoxic injury to LLC-PK1 cells

✍ Scribed by Hagar, Hanan; Ueda, Norishi; Shah, Sudhir V

Book ID
109884656
Publisher
Nature Publishing Group
Year
1996
Tongue
English
Weight
656 KB
Volume
49
Category
Article
ISSN
0085-2538

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Although oxygen is required for normal aerobic respiration, hyperoxia (95% O(2)/5% CO(2)) damages DNA, inhibits proliferation in G1, S and G2 phases of the cell cycle, and induces necrosis. The current study examines whether growth arrest in G1 protects pulmonary epithelial cells from oxidative DNA