Clinical trials with Lipiodol l3ll were started in 1961 by my associate, S. CHIAPPA, and a group of physicians at the Institute of Radiology and the National Cancer Institute in Milan and development has been vigorously pursued during the past years. Once the rationale of this method was established, various aspects of the probΒ lem have been investigated, particularly the distribution of the radioactive dye into the lymph nodes as weIl as its fate and dosimetry in the body tissues. This monoΒ graph describes the extensive clinical evaluation and the radiological results obtained in a large group of patients with malignant lymphomas. Endolymphatic radiotherapy as a therapeutic tool employing radiΓΆnuclides has aroused interest at several meetings concerned with lymphology. In the re cent monoΒ graph "Lymphography in cancer" by W. A. FUCHS, J. W. DAVIDSON and H. W. FISCHER, Dr. JANTET wrote a chapter on this specific subject. Many aspects are still debated, i. e. the choice of radionuclide, the specific clinical indications and the proper evaluation of the therapeutic effects. It is hoped that further studies will come to more precise conclusions.