Endoglin, a component of the TGF-β receptor, regulates extravillous trophoblast differentiation
✍ Scribed by M. Letarte; I. Caniggia; S.J. Lye
- Book ID
- 114116135
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 146 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0143-4004
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Endoglin is an integral membrane glycoprotein that binds transforming growth factor-1 (TGF-1) with high affinity and it is strongly expressed on syncytiotrophoblasts throughout pregnancy. Here, we describe the expression of endoglin by the choriocarcinoma cell line JAR as evidenced by flow cytomet
Endoglin/CD105 is a membrane protein involved in the TGF- receptor signalling pathway. Endoglin expression has been reported to be selective for a few cell types, in particular endothelial cells, although a number of conflicting reports have been published. In this study, we performed a detailed an
## Abstract Endoglin (CD105) is a cell membrane glycoprotein over‐expressed on highly proliferating endothelial cells in culture, and on endothelial cells of angiogenetic blood vessels within benign and malignant tissues. CD105 binds several factors of the Transforming Growth Factor (TGF)‐β superfa