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Endogenous tetrahydroisoquinolines associated with Parkinson’s disease mimic the feedback inhibition of tyrosine hydroxylase by catecholamines

✍ Scribed by Joachim Scholz; Karen Toska; Alexander Luborzewski; Astrid Maass; Volker Schünemann; Jan Haavik; Andreas Moser


Book ID
111312383
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
470 KB
Volume
275
Category
Article
ISSN
1432-1327

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Tyrosine hydroxylase (TH) gene is the ratelimiting enzyme in the synthesis of catecholamines. Functional polymorphisms of the TH gene may be involved in the pathogenesis of neuropsychiatric diseases such as schizophrenia, affective disorders, and Parkinsonism. This study examined a possible associat