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Endogenous steroid hormone levels in early pregnancy and risk of testicular cancer in the offspring: A nested case–referent study

✍ Scribed by Katsiaryna Holl; Eva Lundin; Heljä-Marja Surcel; Kjell Grankvist; Pentti Koskela; Joakim Dillner; Göran Hallmans; Göran Wadell; Gudridur H. Olafsdottir; Helga M. Ögmundsdottir; Eero Pukkala; Matti Lehtinen; Pär Stattin; Annekatrin Lukanova

Publisher
John Wiley and Sons
Year
2009
Tongue
French
Weight
94 KB
Volume
124
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

According to the leading hypothesis on testicular cancer (TC) etiology exposure to a specific pattern of steroid hormones in utero, in particular, to high levels of estrogens and low levels of androgens is the major determinant of TC risk in the offspring. We performed a case–referent study nested within Finnish, Swedish and Icelandic maternity cohorts exploiting early pregnancy serum samples to evaluate the role of maternal endogenous steroid hormones with regard to the risk of TC. TC cases and referents were aged between 0 and 25 years. For each case‐index mother pair, three or four matched referent‐referent mother pairs were identified using national population registries. First trimester or early second trimester sera were retrieved from the index mothers of 73 TC cases and 286 matched referent mothers, and were tested for dehydroepiandrosterone sulfate (DHEAS), androstenedione, testosterone, estradiol, estrone, and sex hormone binding globulin (SHBG). Offspring of mothers with high DHEAS levels had a significantly decreased risk of TC (OR for highest vs. lowest DHEAS quartile, 0.18 (95% CI 0.06–0.58). In contrast, offspring of mothers with high androstenedione levels had an increased risk of TC (OR 4.1; 95% CI 1.2–12.0). High maternal total estradiol level also tended to be associated with an increased risk of TC in the offspring (OR 32; 95% CI 0.98–1,090). We report the first direct evidence that interplay of maternal steroid hormones in the early pregnancy is important in the etiology of TC in the offspring. © 2009 UICC

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