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Endogenous selective inhibitors of 11β-hydroxysteroid dehydrogenase isoforms 1 and 2 of adrenal origin

✍ Scribed by Syed A. Latif; Hector A. Pardo; Matthew P. Hardy; David J. Morris


Book ID
116733760
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
209 KB
Volume
243
Category
Article
ISSN
0303-7207

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## Abstract Renal 11β‐hydroxysteroid dehydrogenase 2 (HSD2) catalyzes the conversion of active glucocorticoids to inert 11β‐keto compounds, thereby preventing the illicit binding of these hormones to mineralocorticoid receptors (MRs) and, thus, conferring aldosterone specificity. Absence or inhibit