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Endogenous pain modulation: Implication of Proteinase-Activated Receptor-4 in physiological and pathophysiological nociception

โœ Scribed by N. Vergnolle; S. Asfaha


Book ID
119305764
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
41 KB
Volume
5
Category
Article
ISSN
1528-8447

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## Abstract ## Objective To investigate the role of proteinaseโ€activated receptor 4 (PARโ€4) in mediating joint inflammation and pain in mice. ## Methods Knee joint blood flow, edema, and pain sensitivity (as induced by thermal and mechanical stimuli) were assessed in C57BL/6 mice following intra